Rockland 组蛋白修饰抗体-技术前沿-资讯-生物在线
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Rockland 组蛋白修饰抗体

作者：杭州联科生物技术股份有限公司 2018-03-22T13:26 (访问量:4601)


Rockland Epi-Plus™ Antibodies-组蛋白修饰抗体


Rockland的高特异性Epi-Plus™抗体可识别经过修饰的组蛋白和相关的细胞靶点，并通过多种检测方法进行验证。Epi-Plus™抗体对这种修饰是特别灵敏和特异的，并且对相同位点或该蛋白其他氨基酸的其他修饰没有交叉反应。免疫荧光显微技术（IF）、免疫沉淀（IP）、染色质免疫沉淀（ChIP）、免疫组织化学（IHC）和蛋白印迹（WB）的分析验证了Epi-Plus™抗体的有效性。


翻译后修饰（PTM）如组蛋白的甲基化、乙酰化和磷酸基化等都是调节基因表达调控、DNA修复、染色体凝缩和精子形成的关键部分。许多蛋白质已经被确认形成了复合物，能够调节组蛋白修饰。这个多组件的细胞机器被称为“读者、作家和橡皮擦”。这些组蛋白修饰复合物的功能变化被认为破坏了组蛋白标记的结构和水平，从而解除了基于核染色质的过程控制，最终导致致癌转化和癌症的发展。与此一致的是，组蛋白PTM的异常模式与大量的人类恶性肿瘤有关。Rockland提供了针对大多数修饰和修饰对的抗体。

图为组蛋白翻译后修饰图


优势：

Rockland提供染色质和核信号抗体的组合，是表观遗传学研究的高品质试剂。在严格的质量控制测试下，Rockland生产抗组蛋白PTMs的抗体。这种Epi-Plus抗体是经过多种试验验证的，包括利用修饰过的肽阵、western blots和染色质免疫沉淀（ChIP）进行的斑点印迹检测。这确保成品符合或超过我们的高标准，以达到最佳的性能。


Epi-Plus™ 抗体推荐：

用于Histone 3 K4 甲基化

厂商 货号 名称
Rockland 600-401-I57 Anti-Histone H3 [Monomethyl Lys4] (RABBIT) Antibody
Rockland 600-401-I58 Anti-Histone H3 [Dimethyl Lys4] (RABBIT) Antibody
Rockland 600-401-I59 Anti-Histone H3 [Trimethyl Lys4] (RABBIT) Antibody



Epi-Plus™ 部分抗体列表：

货号 名称 规格 种属反应
600-401-I52 Histone H3 R2me1 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I53 Histone H3 R2me2a Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I54 Histone H3 K4me1/pT3 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I55 Histone H3 K4me2/pT3 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I56 Histone H3 pT3/K4ac Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I57 Histone H3 K4me1 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I58 Histone H3 K4me2 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I59 Histone H3 K4me3 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I60 Histone H3 K4ac Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I61 Histone H3 K4me1/pT6 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I62 Histone H3 K4me3/pT6 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I63 Histone H3 pT6 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I64 Histone H3 K9me1/pT6 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I65 Histone H3 K9me2/pT6 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I66 Histone H3 K9me3/pT6 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I67 Histone H3 R8me2a Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I68 Histone H3 R8me2s Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I69 Histone H3 K9me1 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I70 Histone H3 K9me2 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I71 Histone H3 K9me3 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I72 Histone H3 K9ac Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I73 Histone H3 K9ac/K14ac Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I74 Histone H3 pS10 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I75 Histone H3 pS10/pT11 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I76 Histone H3 pT11 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I77 Histone H3 R17me2a Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I78 Histone H3 K18me1 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I79 Histone H3 K18me2 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I80 Histone H3 K18me3 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I81 Histone H3 K18ac Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I82 Histone H3 K23ac Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I83 Histone H3 pS28 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I84 Histone H3 K27me3/pS28 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I85 Histone H3 R2me2s/K4me2
Antibody		 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I86 Histone H3 K36me1 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I87 Histone H3 K36me2 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I88 Histone H3 K36me3 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I89 Histone H3 K36ac Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I90 Histone H3 K37me1 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I91 Histone H3 K37me2 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I92 Histone H3 K37me3 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I93 Histone H3 K56me1 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I94 Histone H3 K56me3 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-I95 Histone H3 K79Me3 Antibody 50ug Human, mouse, C. elegans, rat, chicken,
Xenopus, Drosophila, plant
600-401-J98 Histone H3 K4-Me3/K9-Ac Antibody 50ug Human, mouse, rat, C. elegans
600-401-J99 Histone H3 K27me3 Antibody 50ug Human, mouse, rat, C. elegans
600-401-K00 Histone H3 K27ac Antibody 50ug Human, mouse, rat, C. elegans
600-401-K01 Histone H3 K4me2/pT6 Antibody 50ug Human, mouse, rat, C. elegans
600-401-K02 Histone H3 K23me2 Antibody 50ug Human, mouse, rat, C. elegans
600-401-M75 Histone H3 K27 methyl Antibody 50ug Human, mouse, rat, C. elegans
600-401-P08 Histone H3 K9-Ac/pS10
(RABBIT) Antibody		 50ug Human
600-401-P10 Histone H3 K79-Me1 Antibody 50ug Human, Mouse, Primate, C. elegans,
Drosophila, Plant, Rat, Xenopus
600-401-P14 Histone H3 pT3/R2-Me2s Antibody 50ug Human
600-401-V34 Histone H3 K27 me2 Antibody 50ug Human
600-401-W54 Histone H3 K27 me1 Antibody 50ug Human
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