FLT3 monoclonal antibody, clone BV10A4H2
产品名称: FLT3 monoclonal antibody, clone BV10A4H2
英文名称: FLT3 monoclonal antibody, clone BV10A4H2
产品编号: MAB0663
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native FLT3.
- Immunogen:
- Native purified FLT3 from human BV-173 pro-B cell line.
- Host:
- Mouse
- Theoretical MW (kDa):
- 130-150
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.5% BSA, 0.1% sodium azide)
- Storage Instruction:
- Store at 4°C.
- Recommend Usage:
- Flow Cytometry (5 ul per 106 cells in a 100 ul total staining volume)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Application Image
- Flow Cytometry
- Entrez GeneID:
- 2322
- Gene Name:
- FLT3
- Gene Alias:
- CD135,FLK2,STK1
- Gene Description:
- fms-related tyrosine kinase 3
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq
- Other Designations:
- CD135 antigen,FL cytokine receptor,FLT3 receptor tyrosine kinase,OTTHUMP00000042340,fetal liver kinase 2,growth factor receptor tyrosine kinase type III,stem cell tyrosine kinase 1,tyrosine-protein kinase receptor FLT3
- Related Disease
- Acute Disease
- Cardiovascular Diseases
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Diabetes Mellitus, Type 2
- Disease Progression
- Down Syndrome
- Edema
- Fractures, Spontaneous
- Genetic Predisposition to Disease
- Leukemia
- Leukemia, B-Cell, Acute
- Leukemia, chronic myeloid
- Leukemia, Lymphocytic, Acute, L1
- Leukemia, Myelocytic, Acute
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid
- Leukemia, Myeloid, Acute
- Leukemia, Myelomonocytic, Chronic