Six2 (NM_011380) Mouse Recombinant Protein
产品名称: Six2 (NM_011380) Mouse Recombinant Protein
英文名称: Six2 (NM_011380) Mouse Recombinant Protein
产品编号: PM47521M5
产品价格: 0
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围: null
安诺伦(北京)生物科技有限公司
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产品概述:Purified recombinant protein of Mouse sine oculis-related homeobox 2 (Six2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug 蛋白长度:A DNA sequence from Mouse cDNA ORF Clone, [GM33768V], encoding Mouse full-length Six2. 表达系统:HEK293T 种属:Mouse 标签类型:C-MYC/DDK 分子量:33.2 kDa 通用名:Six2 总结:Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation (PubMed:20515681). During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1 (PubMed:19660448). During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway (PubMed:18321982). Also may be involved in limb tendon and ligament development (PubMed:7720577). Plays a role in cell proliferation and migration (By similarity).[UniProtKB/Swiss-Prot Function] 形式:Liquid 浓度:>50 ug/mL as determined by microplate BCA method 纯度:> 80% as determined by SDS-PAGE and Coomassie blue staining 储存溶液:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.