FITC标记的2号染色体开放阅读框60抗体
产品名称： FITC标记的2号染色体开放阅读框60抗体
英文名称： Anti-C2orf60/FITC
产品编号： HZ-9809R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-C2orf60/FITC Conjugated antibody
FITC标记的2号染色体开放阅读框60抗体
| 产品编号 | bs-9809R-FITC |
| 英文名称 | Anti-C2orf60/FITC |
| 中文名称 | FITC标记的2号染色体开放阅读框60抗体 |
| 别 名 | Chromosome 2 open reading frame 60; FLJ37953; Hypothetical protein LOC129450; JmjC domain containing protein C2orf60; MGC70509; TYW5_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C2orf60 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: C2orf60, also known as JmjC domain-containing protein C2orf60, FLJ37953 or MGC70509, is a 315 amino acid protein that exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 2q33.1. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome, is related to mutations in the ALMS1 gene. Chromosome 2 contains a probable vestigial second centromere as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes. Function: tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. Subunit: Homodimer. Similarity: Belongs to the TYW5 family. Contains 1 JmjC domain. Database links: Entrez Gene: 129450 Human Entrez Gene: 68736 Mouse Entrez Gene: 301419 Rat SwissProt: A2RUC4 Human SwissProt: A2RSX7 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
C2ORF 60，也称为JMJC结构域，含有蛋白质C2Orf60、FLJ37 953或MGC70509，是一种315个氨基酸的蛋白质，存在于两个可交替拼接的异构体中，这些异构体由映射到人类染色体2q33.1的基因编码。作为第二大人类染色体，2号染色体约占人类基因组的8%，包含2亿3700万个碱基，编码超过1400个基因。许多遗传疾病与2号染色体上的基因有关。HARKQUIN是一种罕见的皮肤畸形，与ABCA12基因的突变有关。脂类代谢紊乱是与ABCG5和ABCG8相关的。ALSTR综合征是一种极为罕见的隐性遗传性疾病，与ALMS1基因突变有关。第2染色体包含可能残留的第二着丝粒和残端粒，这证明了人类染色体2是由于两个祖先染色体的古老融合而形成的假说，这两个祖先染色体仍然存在于现代类人猿中。