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上海信裕生物科技有限公司
CRM1抗体

CRM1抗体

商家询价

产品名称： CRM1抗体

英文名称： CRM1Antibody

产品编号： XY12915-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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CRM1抗体

 Applications

In-house applications ELISA, WB, IHC, IP     Application not tested? Please see our Guarantee.
Species specificity Human,Mouse,Rat; other species not tested.
Images
Prev12NextView more validation data
  • 12915-1-AP;HeLa cellHeLa cells were subjected to SDS PAGE followed by western blot with 12915-1-AP(XPO1 antibody) at dilution of 1:500
  • 12915-1-AP;H-heartImmunohistochemical of paraffin-embedded human heart using 12915-1-AP(XPO1 antibody) at dilution of 1:50 (under 10x lens)
  • 12915-1-AP;H-heartImmunohistochemical of paraffin-embedded human heart using 12915-1-AP(XPO1 antibody) at dilution of 1:50 (under 40x lens)
  • 12915-1-AP;HeLa cellsIP Result of anti-XPO1 (IP:12915-1-AP, 4ug; Detection:12915-1-AP 1:500) with HeLa cells lysate 2800ug.
Positive WB detected in HeLa cells, HT-1080 cells
Positive IP detected in HeLa cells
Positive IHC detected in Human heart tissue, human kidney tissue, human pancreas tissue
Recommended dilution WB : 1:500-1:5000
IP : 1:200-1:2000
IHC : 1:20-1:200
CRM1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen InformationCRM1抗体
Immunogen CRM1 fusion protein ag3488 Full name Exportin 1 (CRM1 homolog, yeast)
Calculated molecular
weight		 1071aa,123 kDa Observed molecular 
weight		 100-110 kDa
GenBank accession 
number		 BC032847 Gene ID (NCBI) 7514
Gene symbol XPO1 Synonyms CRM1, DKFZp686B1823, Exp1, Exportin 1, XPO1
Background

CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal (PMID: 9323133). CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs (PMID: 17317185). In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly (PMID: 22773955). Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target (PMID: 22677130; 21683812 ).CRM1抗体

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