FITC标记的碳酸酐酶2抗体
产品名称： FITC标记的碳酸酐酶2抗体
英文名称： Anti-CA II/FITC
产品编号： HZ-1709R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CA II/FITC Conjugated antibody
FITC标记的碳酸酐酶2抗体
| 英文名称 | Anti-CA II/FITC |
| 中文名称 | FITC标记的碳酸酐酶2抗体 |
| 别 名 | Carbonic anhydrase Ⅱ; CA 2; CA II; CA2; CAII; Car 2; Car2; Carbonate dehydratase II; Carbonic anhydrase 2 ; Carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase II; Carbonic dehydratase. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CA II |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Carbonic anhydrase II (CAII) is a single polypeptide chain of molecular weight 29kDa. It is present in the cytosol of most tissues, but highest concentrations are found, like Carbonic Anhydrase I, in erythrocytes. The concentration in erythrocytes is about 20µM. It catalyses the hydration of CO2 and the hydrolysis of esters. Zn2+ ion cofactor is required for enzyme activity. Certain point mutations occur without apparent clinical effect, however, complete absence leads to mild mental retardation and cerebral calcification, osteoporosis and renal tubular acidosis. Also known as: Carbonic anhydrase Ⅱ; CA 2; CA II; CA2; CAII; Car 2; Car2; Carbonate dehydratase II; Carbonic anhydrase 2 ; Carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase II; Carbonic dehydratase. Function: Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Subunit: Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Subcellular Location: Cytoplasm. DISEASE: Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation. Similarity: Belongs to the alpha-carbonic anhydrase family. Database links: Entrez Gene: 760 Human Entrez Gene: 12349 Mouse Omim: 611492 Human SwissProt: P00918 Human SwissProt: P00920 Mouse Unigene: 155097 Human Unigene: 1186 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CA2(Carbonic anhydrase1)也是红细胞的主要蛋白质成分之一,是一种重要的锌酶，对血液及组织起到维持酸碱平衡的作用，协助体内组织排除二氧化碳，碳酸酐酶Ⅱ参与呼吸、钙化、酸碱平衡、骨吸收和各种体液形成的生理过程 |
Carbonic anhydrase II（CAII）是分子量为29 kDa的单一多肽链。它存在于大多数组织的细胞质中，但是在红细胞中发现最高浓度，如碳酸酐酶I。红细胞中的浓度约为20μm。它催化CO2的水化和酯的水解。Zn2+离子辅因子是酶活性所必需的。某些点突变的发生没有明显的临床效果，然而，完全缺失导致轻度智力低下和脑钙化，骨质疏松和肾小管酸中毒。又称：碳酸酐酶Ⅱ；CA2；CAII；CA2；CAII；Car2；Car2；碳酸脱水酶II；碳酸酐酶2；碳酸酐酶B；碳酸酐酶C；碳酸酐酶II；碳酸脱水酶。