FITC标记的Bcl2蛋白修饰因子抗体
产品名称： FITC标记的Bcl2蛋白修饰因子抗体
英文名称： Anti-Bcl2 modifying factor/FITC
产品编号： HZ-7587R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Bcl2 modifying factor/FITC Conjugated antibody
FITC标记的Bcl2蛋白修饰因子抗体
| 英文名称 | Anti-Bcl2 modifying factor/FITC |
| 中文名称 | FITC标记的Bcl2蛋白修饰因子抗体 |
| 别 名 | Bcl 2 modifying factor; Bcl-2-modifying factor; Bcl2 modifying factor; Bmf; BMF_HUMAN; FLJ00065. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞凋亡 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Bcl2 modifying factor (54-88aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The BH3-only proteins, which include Blk, Bad, Bik, Hrk, BID, Bim, NOXA, PUMA and Bmf, are proapoptotic members of the Bcl-2 family. Bcl-2 modifying factor (Bmf) is a BH3-only protein that binds prosurvival Bcl-2 family members to initiate apoptosis. Bmf is sequestered to Myosin V motors on Actin in the cytoskeleton by associating with Dynein light chain 2 (DLC2) homodimers. If the cell undergoes loss of attachment (anoikis), the cytoskeleton is disrupted and Bmf is released from DLC2. Bmf then translocates to the mitochondria, where Bcl-2 (an anti-apoptotic family member) is sequestered. The BH3 domain of Bmf facilitates binding to a hydrophobic groove on the surface of Bcl-2. Binding results in a caspase cascade leading to apoptosis. Bmf is widely expressed in tissues such as pancreas, liver and kidney, and in hematopoietic tissues. The gene encoding Bmf maps to chromosome 15q14. Function: May play a role in apoptosis. Isoform 1 seems to be the main initiator. Subunit: Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2 Tissue Specificity: Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Similarity: Belongs to the Bcl-2 family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
BH3仅蛋白，包括BLK、BAD、BIK、HRK、BID、BIM、NOXA、彪马和BMF，是Bcl-2家族的促凋亡成员。Bcl-2修饰因子（BMF）是一种BH3蛋白，它与生存期Bcl-2家族成员结合以启动细胞凋亡。Bmf通过肌动蛋白轻链2（DLC2）同聚二聚体与肌动蛋白在肌动蛋白骨架上被分离到肌球蛋白V马达上。如果细胞遭受附着丧失（ANOIKIS），细胞骨架被破坏，Bmf从DLC2释放。然后，Bmf转位到线粒体，其中Bcl-2（抗凋亡家族成员）被隔离。BM3的BH3结构域促进结合到Bcl-2表面上的疏水沟槽。结合导致Caspase级联导致细胞凋亡。BMF在胰腺、肝、肾等组织中广泛表达，在造血组织中广泛表达。编码BMF的基因定位于染色体15q14。