FITC标记的磷酸化皮层肌动蛋白抗体
产品名称： FITC标记的磷酸化皮层肌动蛋白抗体
英文名称： Anti-phospho-Cortactin (Tyr466)/FITC
产品编号： HZ-3100R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-Cortactin (Tyr466)/FITC Conjugated antibody
FITC标记的磷酸化皮层肌动蛋白抗体
| 英文名称 | Anti-phospho-Cortactin (Tyr466)/FITC |
| 中文名称 | FITC标记的磷酸化皮层肌动蛋白抗体 |
| 别 名 | Cortactin (phospho Tyr466); Cortactin (phospho Y466); p-Cortactin (phospho Y466); Amplaxin; CTTN; EMS 1; EMS1; Mammary tumor and squamous cell carcinoma associated; Oncogene EMS1; p80/85 src substrate; Src substrate cortactin; SRC8_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 61kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Cortactin around the phosphorylation site of Tyr466(YAp-TEA) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010] Function: Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases. Subunit: Interacts with SHANK2 and SHANK3 (via its SH3 domain). Also interacts with FGD1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts with PLXDC2 and SRCIN1. Interacts with SAMSN1 (via SH3 domain). Interacts (via SH3 domain) with ASAP1 (via Pro-rich region). Interacts with DNM2 and FER. Binds to MYLK. A complex made of ABL1, CTTN and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Post-translational modifications: Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin. Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding. Similarity: Contains 7 cortactin repeats. Contains 1 SH3 domain. Database links: Entrez Gene: 2017 Human GenBank: NM_138565 Human Omim: 164765 Human SwissProt: Q14247 Human Unigene: 596164 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 皮层肌动蛋白（cortactin）是一种微丝肌动蛋白结合蛋白,其主要参与细胞骨架系统的调控,细胞外信号转导以及细胞黏附等过程,cortactin与肿瘤的侵袭和转移有关 |
该基因在乳腺癌和头颈部鳞状细胞癌中过表达。编码的蛋白质定位在细胞质中和细胞底层接触的区域。该基因具有两个作用：（1）调节黏附型结的组分之间的相互作用，（2）组织上皮细胞和癌细胞的细胞骨架和细胞粘附结构。在凋亡过程中，编码的蛋白以caspase依赖的方式降解。该基因的异常调控有助于肿瘤细胞的侵袭和转移。三个剪接变异体，编码不同的异构体已经确定了这个基因。[ RefSeq，2010年5月提供]