FITC标记的胰岛素基因增强结合蛋白2抗体
产品名称： FITC标记的胰岛素基因增强结合蛋白2抗体
英文名称： Anti-Islet 2/FITC
产品编号： HZ-11321R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Islet 2/FITC Conjugated antibody
FITC标记的胰岛素基因增强结合蛋白2抗体
| 产品编号 | bs-11321R-FITC |
| 英文名称 | Anti-Islet 2/FITC |
| 中文名称 | FITC标记的胰岛素基因增强结合蛋白2抗体 |
| 别 名 | Insulin gene enhancer protein ISL 2; Insulin gene enhancer protein ISL-2; Insulin gene enhancer protein ISL2; ISL 2; ISL 2 transcription factor; ISL 2 transcription factor LIM/homeodomain; ISL2; ISL2 transcription factor; ISL2 transcription factor LIM/homeodomain; ISL2_HUMAN; Islet-2; Islet2; FLJ10160. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Islet 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Islet-2 (insulin gene enhancer protein ISL-2) is a 359 amino acid protein encoded by the human gene ISL2. Islet-2 is a nuclear protein that contains two N-terminal LIM domains, followed by a homeodomain and a serine/ glutamine/threonine-rich C-terminus. Islet-2 is a transcriptional factor that defines subclasses of motor neurons that segregate into columns in the spinal cord and select distinct axon pathways. Islet-1 and Islet-2 are initially ex-pressed by all postmitotic spinal motor neurons prior to diversification of somatic and visceral neuronal fates. Somatic, but not visceral, motor neurons maintain Islet-2 expression at later embryonic stages. An early phase of Islet-2 expression by prospective visceral motor neurons of the sympathetic preganglionic motor column is critical for the emergence of complete visceral motor neuron character. Mutations that reduce or eliminate both Islet-1 and Islet-2 activity will result in pronounced defects in visceral motor neuron generation and eroded somatic motor neuron character. Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Subcellular Location: Nucleus. Similarity: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. Database links: UniProtKB/Swiss-Prot: Q96A47.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IsLIT-2（胰岛素基因增强子蛋白ISL-2）是由人基因ISL2编码的359氨基酸蛋白。IsLIT-2是含有两个N-末端LIM结构域的核蛋白，其次是同源结构域和丝氨酸/谷氨酰胺/苏氨酸丰富的C-末端。IsLET-2是一种转录因子，它定义了运动神经元的亚类，它们在脊髓中分离成柱，并选择不同的轴突通路。IsLIT-1和IsLIT-2最初被所有有丝分裂后脊髓运动神经元压迫，在体细胞和内脏神经元命运多样化之前。体细胞，但不是内脏，运动神经元维持IsLIT-2表达在后期胚胎阶段。IsLIT-2的早期表达是由交感节前运动柱的预期内脏运动神经元对完整的内脏运动神经元特征的出现所引起的。减少或消除IsLIT-1和IsLIT-2活性的突变将导致内脏运动神经元的产生和侵蚀体细胞运动神经元特征的明显缺陷。