FITC标记的脑发育同源蛋白1抗体
产品名称： FITC标记的脑发育同源蛋白1抗体
英文名称： Anti-DBX1/FITC
产品编号： HZ-11199R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DBX1/FITC Conjugated antibody
FITC标记的脑发育同源蛋白1抗体
| 产品编号 | bs-11199R-FITC |
| 英文名称 | Anti-DBX1/FITC |
| 中文名称 | FITC标记的脑发育同源蛋白1抗体 |
| 别 名 | dbx; Developing brain homeobox 1; Developing brain homeobox protein 1; DBX1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 干细胞 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DBX1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Dbx1 homeodomain transcription factor is expressed in progenitors at the boundary between the dorsal and ventral plates of the caudal neural tube, from which postmitotic cells migrate tangentially to their final destination. Dbx1 is implicated in patterning the central nervous system during embryogenesis. Cell fate allocation and cell diversity are determined at very early stages in progenitor cells at precise coordinates along the dorsoventral and anteroposterior axis. In the spinal cord, the spatially restricted expression of Dbx1 in progenitors is critical in establishing interneuron cell fates and helps coordinate diverse phenotypic features. In the telencephalon, Dbx1 is expressed in restricted progenitor domains at the borders of the developing pallium. Function: Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity). Subcellular Location: Nuclear Similarity: Belongs to the H2.0 homeobox family. Contains 1 homeobox DNA-binding domain. Database links: UniProtKB/Swiss-Prot: A6NMT0.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Dbx1同源结构域转录因子在尾神经管的背侧和腹侧板之间的边界上表达，其中有丝分裂细胞从切向迁移到最终目的地。DX1与胚胎发育过程中中枢神经系统的图案化有关。细胞命运分配和细胞多样性在非常早的阶段确定在祖细胞在精确坐标沿着背腹和前后轴。在脊髓中，DXX1在祖细胞中的空间限制性表达对于建立中间神经元细胞命运至关重要，并有助于协调不同的表型特征。在端脑中，Dbx1在发育中的大脑皮层的边界上在限制性祖细胞域中表达。