FITC标记的溶血磷脂酸酰基转移酶β抗体
产品名称： FITC标记的溶血磷脂酸酰基转移酶β抗体
英文名称： Anti-Agpat2/FITC
产品编号： HZ-5032R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Agpat2/FITC Conjugated antibody
FITC标记的溶血磷脂酸酰基转移酶β抗体
| 英文名称 | Anti-Agpat2/FITC |
| 中文名称 | FITC标记的溶血磷脂酸酰基转移酶β抗体 |
| 别 名 | LPAAB; BSCL; BSCL1; EC 2.3.1.51; LPAAB; LPAAT beta; Lysophosphatidic acid acyltransferase beta; 1 acyl sn glycerol 3 phosphate acyltransferase beta; 1 acylglycerol 3 phosphate O acyltransferase 2; 1 AGP acyltransferase 2; 1 AGPAT2 antibody Berardinelli Seip congenital lipodystrophy.PLCB_HUMAN |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LPAAB |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Agpat2 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. It is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in its have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Subcellular Location: Membrane; Multi-pass membrane protein Tissue Specificity: Expressed predominantly in heart and liver. DISEASE: Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 (CGL1) [MIM:608594]; also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1) or Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. Database links: Entrez Gene: 10555 Human Entrez Gene: 67512 Mouse Entrez Gene: 311821 Rat Omim: 603100 Human SwissProt: O15120 Human SwissProt: Q8K3K7 Mouse Unigene: 320151 Human Unigene: 24244 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
AgPAT2是1-酰基甘油-3-磷酸-O-酰基转移酶家族的成员。它位于内质网膜内，并将溶血磷脂酸转化为磷脂酸，这是从头磷脂合成的第二步。其突变与先天性全身性脂肪营养不良（CGL）或BARARDNELI SEIP综合征有关，该疾病的特征是脂肪组织的缺乏和严重的胰岛素抵抗。编码不同的异构体的交替转录剪接变异体已被表征。