FITC标记的Jun激活区域-连接蛋白1抗体
产品名称： FITC标记的Jun激活区域-连接蛋白1抗体
英文名称： Anti-Jab1/COPS5/FITC
产品编号： HZ-1394R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Jab1/COPS5/FITC Conjugated antibody
FITC标记的Jun激活区域-连接蛋白1抗体
| 英文名称 | Anti-Jab1/COPS5/FITC |
| 中文名称 | FITC标记的Jun激活区域-连接蛋白1抗体 |
| 别 名 | 38 kDa Mov34 homolog; COP9 (constitutive photomorphogenic) homolog subunit 5; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; COP9 signalosome subunit 5; Cop9 subunit 5; COPS 5; COPS5; CSN 5; CSN5; JAB 1; Jun activation domain binding protein 1; Jun activation domain-binding protein; MGC3149; MOV 34; MOV34; SGN 5; SGN5; Signalosome subunit 5; CSN5_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞周期蛋白 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Jab1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B). The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, CDKN1B, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Interacts with IFIT3. Interacts with BRSK2. Subcellular Location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Nuclear localization is diminished in the presence of IFIT3. Similarity: Belongs to the peptidase M67A family. CSN5 subfamily. Contains 1 MPN (JAB/Mov34) domain. Database links: Entrez Gene: 10987 Human Entrez Gene: 26754 Mouse Entrez Gene: 312916 Rat Omim: 604850 Human SwissProt: Q92905 Human SwissProt: O35864 Mouse Unigene: 491912 Human Unigene: 402384 Mouse Unigene: 2243 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子（Transcriptin Regulators） Jab1是一种多功能蛋白质,能与多种蛋白发生相互作用,调控多种细胞内信号转导通路。JAB1也可增强多种转录因子的活性 |
该基因编码的蛋白是COP9信号体的八个亚基之一，COP9信号体是一种高度保守的蛋白质复合物，在多种信号途径中起着重要的调节作用。COP9信号质体的结构和功能与26S蛋白酶体19S调控颗粒相似。COP9信号体已显示与SCF型E3泛素连接酶相互作用，并作为E3泛素连接酶的阳性调节剂。据报道，该蛋白参与了细胞周期蛋白依赖性激酶抑制剂CDKN1B/p27Kip1的降解。它也被称为共激活剂，增加了JUN/AP1转录因子的特异性。