FITC标记的细胞分裂周期相关蛋白5抗体
产品名称： FITC标记的细胞分裂周期相关蛋白5抗体
英文名称： Anti-CDCA5/FITC
产品编号： HZ-7717R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-CDCA5/FITC Conjugated antibody
FITC标记的细胞分裂周期相关蛋白5抗体
| 英文名称 | Anti-CDCA5/FITC |
| 中文名称 | FITC标记的细胞分裂周期相关蛋白5抗体 |
| 别 名 | Cell division cycle associated protein 5; MGC16386; p35; Sororin; CDCA5_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 染色质和核信号 细胞周期蛋白 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDCA5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Sororin, also designated cell division cycle-associated protein 5 (CDCA5) or p35, functions as a regulator of sister chromatid cohesion during mitosis. It interacts with the APC/C complex and is found in a complex consisting of cohesion components SCC-112, MC1L1, SMC3L1, RAD21 and APRIN. The deduced human and mouse Sororin proteins consist of 252 and 264 amino acid residues, respectively, and both contain a KEN box for APC-dependent ubiquitination. Reserach demonstrates a punctated nuclear distribution of Sororin during interphase and a diffuse distribution throughout the cell during mitosis. There is no apparent concentration of Sororin on chromatin in mitotic cells and Sororin levels decrease in synchronized HeLa cells during interphase. The Sororin gene maps to chromosome 11q12.1. Function: CDCA5 is a regulator of sister chromatid cohesion in mitosis. It may act by regulating the ability of the cohesin complex to mediate sister chromatid cohesion, perhaps by altering the nature of the interaction of cohesin with the chromosomes. CDCA5 interacts with the APC/C complex and is found in a complex with the cohesin components SMC1L1, SMC3L1, RAD21, PDS5A/APRIN and PDS5B/SCC-112. Subunit: Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPAL. Subcellular Location: Nuclear. Post-translational modifications: Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPAL by CDCA5. Ubiquitinated by the APC/C complex in G1, leading to its degradation (Probable). Similarity: Belongs to the sororin family. Database links: UniProtKB/Swiss-Prot: Q96FF9.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Sororin，也指定细胞分裂周期相关蛋白5（CDCA5）或P35，作为调节剂姐妹染色单体凝聚力在有丝分裂期间。它与APC/C络合物相互作用，并发现在一个由内聚成分SCC-112、MC1L1、SMC3L1、RAD21和APRIN组成的复合物中。推导的人和小鼠索罗林蛋白分别由252个氨基酸残基和264个氨基酸残基组成，它们都含有APC依赖泛素化的肯盒。SARORIN显示有丝分裂期间SoRRIN的点状核分布，以及在有丝分裂过程中弥漫分布在整个细胞中。Surrin在分裂期HeLa细胞中的染色质没有明显的浓度，Surrin水平降低。SoRoRIN基因定位于染色体11q121。