KCNN3 (Human) Recombinant Protein (Q01)
产品名称： KCNN3 (Human) Recombinant Protein (Q01)
英文名称： KCNN3 (Human) Recombinant Protein (Q01)
产品编号： H00003782-Q01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human KCNN3 partial ORF ( NP_740752, 301 a.a. - 410 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- QAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIG
- Theoretical MW (kDa):
- 37.84
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 3782
- GeneBank Accession#:
- NM_170782
- Protein Accession#:
- NP_740752
- Gene Name:
- KCNN3
- Gene Alias:
- KCa2.3,SK3,SKCA3,hSK3
- Gene Description:
- potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
- Omim ID:
- 602983
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions. [provided by RefSeq
- Other Designations:
- OTTHUMP00000035369,OTTHUMP00000042458,OTTHUMP00000042459,small conductance calcium-activated potassium channel protein 3
- Related Disease
- Anorexia Nervosa
- Atrial Fibrillation
- Atrioventricular Block
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Bipolar Disorder
- Bulimia
- Ductus Arteriosus, Patent
- Genetic Predisposition to Disease
- Infant, Premature, Diseases
- Migraine Disorders
- Myotonic Dystrophy
- Myotonic dystrophy
- NARP
- Psychiatric Status Rating Scales
- Psychotic Disorders
- Schizophrenia
- Schizophrenia
- Spinocerebellar ataxia