STAT5A (phospho S726) Peptide
产品名称: STAT5A (phospho S726) Peptide
英文名称: STAT5A (phospho S726) Peptide
产品编号: P1426
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of STAT5A.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S726 of human STAT5A.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation.
Defilippi P, Rosso A, Dentelli P, Calvi C, Garbarino G, Tarone G, Pegoraro L, Brizzi MF.J Cell Biol. 2005 Mar 28;168(7):1099-108.
- 2.
- Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.
Martens N, Uzan G, Wery M, Hooghe R, Hooghe-Peters EL, Gertler A.J Biol Chem. 2005 Apr 8;280(14):13817-23. Epub 2005 Jan 26.
- 3.
- Physical and functional interactions between STAP-2/BKS and STAT5.
Sekine Y, Yamamoto T, Yumioka T, Sugiyama K, Tsuji S, Oritani K, Shimoda K, Minoguchi M, Yoshimura A, Matsuda T.J Biol Chem. 2005 Mar 4;280(9):8188-96. Epub 2004 Dec 17.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of STAT5A (phospho S726) polyclonal antibody (Cat # PAB0620) in CEM cell lysate (35 ug/lane). Phospho-STAT5A (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with STAT5A (phospho S726) polyclonal antibody (Cat # PAB0620) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 6776
- Protein Accession#:
- NP_003143;P42229
- Gene Name:
- STAT5A
- Gene Alias:
- MGF,STAT5
- Gene Description:
- signal transducer and activator of transcription 5A
- Omim ID:
- 601511
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq
- Other Designations:
- -
- Interactome
- Related Disease
- Asthma
- Asthma
- Birth Weight
- Breast cancer
- Breast Neoplasms
- Bronchiolitis, Viral
- Carcinoma, Hepatocellular
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- Genetic Predisposition to Disease
- Glioblastoma
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- Meningioma