FITC标记的锌指蛋白231抗体
产品名称： FITC标记的锌指蛋白231抗体
英文名称： Anti-Bassoon/FITC
产品编号： HZ-0275R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Bassoon/FITC Conjugated antibody
FITC标记的锌指蛋白231抗体
| 英文名称 | Anti-Bassoon/FITC |
| 中文名称 | FITC标记的锌指蛋白231抗体 |
| 别 名 | Bassoon; BSN; KIAA0434; Neuronal double zinc finger protein; Presynaptic cytomatrix protein; Protein bassoon; Zinc finger protein 231; ZNF 231; ZNF231; Neuronal double zinc finger protein; Zinc-finger protein 231; BSN_HUMAN; ZNF 231. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 锌指蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 432kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BSN (2901-3000aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]. Function: Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses. Subunit: Interacts with ERC2/CAST1, RIMS1 and UNC13A. Part of a complex consisting of ERC2, RIMS1 and BSN. Subcellular Location: Cytoplasm. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density. Tissue Specificity: Exclusively expressed in brain. Post-translational modifications: Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization. Database links: Entrez Gene: 8927 Human Entrez Gene: 12217 Mouse Entrez Gene: 29138 Rat Omim: 604020 Human SwissProt: O43161 Human SwissProt: Q9UPA5 Human SwissProt: O88737 Mouse SwissProt: O88778 Rat Unigene: 194684 Human Unigene: 20425 Mouse Unigene: 29999 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 锌指蛋白是80年代中期发现的一类DNA结合蛋白，在真核生物中,锌指蛋白可能是最大的一类DNA结合蛋白，并且由锌指蛋白调控基因表达是发育和其他过程的一个非常普遍的现象。在最近的几年中，发现某些锌指蛋白对肌肉的发育具有重要的调节作用 |
神经递质从轴突末端的特定部位释放出来，称为活性区，由突触小泡和位于质膜下面的细胞骨架网组成。由该基因编码的蛋白质被认为是参与组织突触前细胞骨架的支架蛋白。该基因主要在大脑中的神经元表达。在啮齿动物中，类似的基因产物集中在轴突终末的活性区，并与细胞骨架结构紧密相关，并且对于调节来自突触子集的神经递质的释放是必不可少的。[ RefSeq，JUL 2008 ]提供。