Impact (NM_008378) Mouse Recombinant Protein
产品名称: Impact (NM_008378) Mouse Recombinant Protein
英文名称: Impact (NM_008378) Mouse Recombinant Protein
产品编号: PM47323M5
产品价格: 0
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围: null
安诺伦(北京)生物科技有限公司
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产品概述:Purified recombinant protein of Mouse impact, RWD domain protein (Impact), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug 蛋白长度:A DNA sequence from Mouse cDNA ORF Clone, [GM34222V], encoding Mouse full-length Impact. 表达系统:HEK293T 种属:Mouse 标签类型:C-MYC/DDK 分子量:36.3 kDa 通用名:Impact 总结:Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis (PubMed:15937339, PubMed:23447528, PubMed:24333428). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (PubMed:15937339, PubMed:23447528). Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth (PubMed:23447528).[UniProtKB/Swiss-Prot Function] 形式:Liquid 浓度:>50 ug/mL as determined by microplate BCA method 纯度:> 80% as determined by SDS-PAGE and Coomassie blue staining 储存溶液:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. 别名:E430016J11Rik