FGR (N-term) Peptide
产品名称： FGR (N-term) Peptide
英文名称： FGR (N-term) Peptide
产品编号： P2750
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of FGR.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human FGR.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Inhibition of receptor-dependent urokinase signaling by specific Ser to Glu substitutions.
Carriero MV, Franco P, Gargiulo L, Vocca I, Cito L, Fontana L, Iaccarino C, Del Pozzo G, Guardiola J, Stoppelli MP.Biol Chem. 2002 Jan;383(1):107-13.
- 2.
- Primary structure of the human fgr proto-oncogene product p55c-fgr.
Katamine S, Notario V, Rao CD, Miki T, Cheah MS, Tronick SR, Robbins KC.Mol Cell Biol. 1988 Jan;8(1):259-66.
- 3.
- Structure, expression, and chromosomal location of the human c-fgr gene.
Nishizawa M, Semba K, Yoshida MC, Yamamoto T, Sasaki M, Toyoshima K.Mol Cell Biol. 1986 Feb;6(2):511-7.
- Applications
- Western Blot (Cell lysate)
- The FGR polyclonal antibody (Cat # PAB3425) is used in Western blot to detect FGR in Ramos cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with FGR polyclonal antibody (Cat # PAB3425) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 2268
- Protein Accession#:
- P09769
- Gene Name:
- FGR
- Gene Alias:
- FLJ43153,MGC75096,SRC2,c-fgr,c-src2,p55c-fgr,p58c-fgr
- Gene Description:
- Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
- Omim ID:
- 164940
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
- Other Designations:
- OTTHUMP00000003601,OTTHUMP00000003602,OTTHUMP00000003603,c-fgr protooncogene,c-src-2 proto-oncogene,p55-c-fgr protein,proto-oncogene tyrosine-protein kinase FGR
- Gene Pathway
- Related Disease