BAD (C-term) Peptide
产品名称： BAD (C-term) Peptide
英文名称： BAD (C-term) Peptide
产品编号： P0335
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of BAD.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human BAD.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75.
Zhang B, Zhang Y, Shacter E.Mol Cell Biol. 2004 Jul;24(14):6205-14.
- 2.
- Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions.
Ong CS, Tran E, Nguyen TT, Ong CK, Lee SK, Lee JJ, Ng CP, Leong C, Huynh H.Oncol Rep. 2004 Mar;11(3):727-33.
- 3.
- Inactivating mutations of proapoptotic Bad gene in human colon cancers.
Lee JW, Soung YH, Kim SY, Nam SW, Kim CJ, Cho YG, Lee JH, Kim HS, Park WS, Kim SH, Lee JY, Yoo NJ, Lee SH.Carcinogenesis. 2004 Aug;25(8):1371-6. Epub 2004 Mar 19.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of BAD polyclonal antibody (Cat # PAB2446) in HeLa cell line lysates (35 ug/lane). BAD (arrow) was detected using the purified polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with BAD polyclonal antibody (Cat # PAB2446) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 572
- Protein Accession#:
- NP_116784;Q92934
- Gene Name:
- BAD
- Gene Alias:
- BBC2,BCL2L8
- Gene Description:
- BCL2-associated agonist of cell death
- Omim ID:
- 603167
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq
- Other Designations:
- BCL-X/BCL-2 binding protein,BCL2-antagonist of cell death protein,BCL2-binding component 6,BCL2-binding protein
- Gene Pathway
- Acute myeloid leukemia
- Alzheimer's disease
- Amyotrophic lateral sclerosis (ALS)
- Apoptosis
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Insulin signaling pathway
- Melanoma
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- VEGF signaling pathway