FITC标记的间充质同源盒蛋白2抗体
产品名称： FITC标记的间充质同源盒蛋白2抗体
英文名称： Anti-MEOX 2/FITC
产品编号： HZ-7031R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-MEOX 2/FITC Conjugated antibody
FITC标记的间充质同源盒蛋白2抗体
| 英文名称 | Anti-MEOX 2/FITC |
| 中文名称 | FITC标记的间充质同源盒蛋白2抗体 |
| 别 名 | GAX; Growth arrest-specific homeobox; Homeobox protein MOX 2; Homeobox protein MOX-2; meox2; MEOX2_HUMAN; Mesenchyme homeobox 2; MOX2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 神经生物学 信号转导 细胞因子 Alzheimer's |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MEOX 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Closely related homeobox proteins, MOX-1 and MOX-2, belong to a family of nonclustered, diverged homeobox genes that are expressed in overlapping patterns in the paraxial mesoderm and its derivatives. MOX-1 and MOX-2 function transiently in the formation of mesodermal and mesenchymal derivatives. MOX-1 and MOX-2 are implicated in the early steps of mesoderm formation during gastrulation. In addition, the MOX proteins are also involved in somatic differentiation. Significantly, MOX-1 associates more strongly with Pax-1, whereas MOX-2 preferentially associates with Pax-3. Specifically, expression of MOX-2 (also known as mesenchyme homeobox 2 or GAX), has been shown to be critical in axial skeleton development. MOX-2 is not needed for the migration of myogenic precursors into the limb bud, but it is essential for normal appendicular muscle formation and for the normal regulation of myogenic genes. MOX-2 is expressed in placental tissue. The human MEOX2 gene maps to chromosome 7p21.1 and encodes the MOX-2 protein. Mutations in the gene may be involved in craniofacial and/or skeletal abnormalities. Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. Subunit: Interacts with RNF10. Subcellular Location: Nucleus. Tissue Specificity: Embryo and placenta. Similarity: Contains 1 homeobox DNA-binding domain. Database links: UniProtKB/Swiss-Prot: P50222.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
密切相关的同源盒蛋白，MOX-1和MOX-2，属于非集群，发散同源框基因，在重叠模式中表达的近轴中胚层及其衍生物。MOX-1和MOX-2在中胚层和间充质衍生物的形成中瞬时发挥作用。MOX-1和MOX-2与肠化过程中胚层形成的早期步骤有牵连。此外，MOX蛋白也参与体细胞分化。值得注意的是，MOX-1与PAX-1的相关性更强，而MOX-2优先与PAX-3相关。具体而言，表达的MOX-2（也称为间充质同源盒2或GAX），已被证明是关键的轴向骨骼发育。MYX-2不需要肌源性前体进入肢体芽，但它对于正常的阑尾肌肉形成和肌源基因的正常调节是必不可少的。MOX-2在胎盘组织中表达。人MEXO2基因定位于染色体721.1，编码MOX-2蛋白。该基因的突变可能涉及颅面和/或骨骼异常。