FITC标记的类泛素蛋白1抗体
产品名称： FITC标记的类泛素蛋白1抗体
英文名称： Anti-SUMO 1/FITC
产品编号： HZ-1499R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SUMO 1/FITC Conjugated antibody
FITC标记的类泛素蛋白1抗体
| 英文名称 | Anti-SUMO 1/FITC |
| 中文名称 | FITC标记的类泛素蛋白1抗体 |
| 别 名 | small ubiquitin-related modifier 1; GAP modifying protein 1; GAP-modifying protein 1; GMP 1; GMP1; PIC 1; PIC1; SENP2; Sentrin 1; Sentrin; Small ubiquitin related modifier 1; SMT3; SMT3 homolog 3; SMT3 suppressor of mif two 3 homolog 1; SMT3C; SMT3H3; Sumo1; Ubiquitin homology domain protein PIC1; Ubiquitin Like 1; Ubiquitin like protein SMT3C; Ubiquitin like protein UBL1; Ubiquitin-like protein UBL1; UBL 1; UBL1; SUMO1_HUMAN; SUMO-1;Ubiquitin-like protein SMT3C; Smt3C. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 合成与降解 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 12kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SUMO 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Subunit: Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52. Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25. Subcellular Location: Nucleus membrane. Nucleus speckle. Cytoplasm. Note=Recruited by BCL11A into the nuclear body. Post-translational modifications: Cleavage of precursor form by SENP1 or SENP2 is necessary for function. Polymeric SUMO1 chains undergo polyubiquitination by RNF4. DISEASE: Defects in SUMO1 are the cause of non-syndromic orofacial cleft type 10 (OFC10) [MIM:613705]; also called non-syndromic cleft lip with or without cleft palate 10. OFC10 is a birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=A chromosomal aberation involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays. Similarity: Belongs to the ubiquitin family. SUMO subfamily. Contains 1 ubiquitin-like domain. Database links: Entrez Gene: 7341 Human Entrez Gene: 22218 Mouse Entrez Gene: 301442 Rat Omim: 601912 Human SwissProt: P63165 Human SwissProt: P63166 Mouse SwissProt: Q5I0H3 Rat Unigene: 596171 Human Unigene: 81424 Human Unigene: 362118 Mouse Unigene: 1221 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） SUMO化能够使蛋白质更加稳定,SUMO的生化反应途径与泛素相似,但不像泛素那样诱导底物蛋白降解.进而调节许多关键的细胞活动. SUMO(small ubiquitin-related modifier)是泛素(ubiqutin)类蛋白家族的重要成员之一 |
该基因编码的蛋白质是SUMO（小泛素样修饰物）蛋白家族的成员。它的功能与泛素相似，因为它作为翻译后修饰系统的一部分与靶蛋白结合。然而，与靶向降解蛋白质的泛素不同，该蛋白涉及多种细胞过程，如核转运、转录调节、细胞凋亡和蛋白质稳定性。直到羧基末端的最后四个氨基酸被切断，它才是活性的。该基因已报道了几种假基因。已经鉴定了编码不同亚型的交替转录剪接变异体。[ RefSeq，JUL 2008 ]