Anti-ALKBH1 Polyclonal Antibody
产品名称: Anti-ALKBH1 Polyclonal Antibody
英文名称: ABH;ABH1;alkB;hABH;ALKBH
产品编号: K006862P
产品价格: null
产品产地: 北京
品牌商标: Solarbio
更新时间: null
使用范围: WB
北京索莱宝科技有限公司--实验室产品
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This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.