FITC标记的细胞分裂周期调控蛋白45抗体
产品名称： FITC标记的细胞分裂周期调控蛋白45抗体
英文名称： Anti-CDC45L/FITC
产品编号： HZ-7785R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CDC45L/FITC Conjugated antibody
FITC标记的细胞分裂周期调控蛋白45抗体
| 英文名称 | Anti-CDC45L/FITC |
| 中文名称 | FITC标记的细胞分裂周期调控蛋白45抗体 |
| 别 名 | CDC 45; CDC 45L; CDC45 (cell division cycle 45, S.cerevisiae homolog) like; CDC45; CDC45 cell division cycle 45 like; CDC45 like; CDC45 related protein; CDC45_HUMAN; CDC45L2; Cell division control protein 45 homolog; Cell division cycle 45 like 2; Cell division cycle 45 like; PORC PI 1; PORC-PI-1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDC45L |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Function: Required for initiation of chromosomal DNA replication.< Subunit: Associated with ORC2. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Widely expressed, highest levels are found in adult testis and thymus and in fetal liver. Similarity: Belongs to the CDC45 family. Database links: Entrez Gene: 8318 Human Entrez Gene: 12544 Mouse Entrez Gene: 287961 Rat Omim: 603465 Human SwissProt: O75419 Human SwissProt: Q9Z1X9 Mouse Unigene: 474217 Human Unigene: 1248 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的蛋白由其与酿酒酵母CDC45的强相似性鉴定，这是启动DNA复制所必需的必需蛋白质。CDC45是高度保守的多蛋白复合物的成员，包括CDC6/CDC18、微染色体维持蛋白（MCMS）和DNA聚合酶，这对于真核生物中DNA复制的早期步骤是重要的。该蛋白已被证明与MCM7和DNA聚合酶α相互作用。对Xenopus相似基因的研究表明，该蛋白在DNA聚合酶α染色质上起关键作用。对该基因已发现编码不同亚型的多个交替剪接转录变体。