FITC标记的甘氨酸受体α1+甘氨酸受体α2抗体
产品名称： FITC标记的甘氨酸受体α1+甘氨酸受体α2抗体
英文名称： Anti-Glycine Receptor alpha 1 + alpha 2/FITC
产品编号： HZ-12090R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Glycine Receptor alpha 1 + alpha 2/FITC Conjugated antibody
FITC标记的甘氨酸受体α1+甘氨酸受体α2抗体
| 英文名称 | Anti-Glycine Receptor alpha 1 + alpha 2/FITC |
| 中文名称 | FITC标记的甘氨酸受体α1+甘氨酸受体α2抗体 |
| 别 名 | GLRA1+GLRA2; GLRA1; GLRA2; Glycine receptor 48 kDa subunit; Glycine receptor alpha 1; Glycine receptor alpha 2; Glycine receptor subunit alpha 1; Glycine receptor subunit alpha 2; Glycine receptor, alpha 1 subunit; Glycine receptor, alpha 2 subunit; STHE; GLRA1_HUMAN; GLRA2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 通道蛋白 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Glycine Receptor alpha 1 + alpha 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glycine receptors are members of the ligand-gated ion channel superfamily, which mediate fast inhibitory neurotransmission. The receptors are pentameric membrane proteins which form chloride channels. Binding of glycine to its receptor produces an increase in chloride conductance and membrane hyperpolarisation. Four genes encoding glycine receptor alpha subunits have been identified, together with a single beta polypeptide. Each subunit consists of a large extracellular N-terminal region, four transmembrane domains, and a large cytoplasmic domain. Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Subunit: Pentamer composed of alpha and beta subunits. Subcellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. DISEASE: Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1) [MIM:149400]. A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily. Database links: Entrez Gene: 2741 Human Entrez Gene: 2742 Human Entrez Gene: 14654 Mouse Entrez Gene: 237213 Mouse Entrez Gene: 24397 Rat Entrez Gene: 25674 Rat Omim: 138491 Human Omim: 305990 Human SwissProt: P23415 Human SwissProt: P23416 Human SwissProt: Q6DJV9 Human SwissProt: Q64018 Mouse SwissProt: Q7TNC8 Mouse SwissProt: P07727 Rat SwissProt: P22771 Rat Unigene: 121490 Human Unigene: 2700 Human Unigene: 113877 Mouse Unigene: 358598 Mouse Unigene: 10109 Rat Unigene: 10379 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
甘氨酸受体是配体门控离子通道超家族成员，介导快速抑制神经传递。受体是五聚体膜蛋白，形成氯离子通道。甘氨酸与其受体的结合产生氯离子传导和膜超极化的增加。已经鉴定出编码甘氨酸受体α亚基的四个基因，以及一个β-多肽。每个亚基由一个大的细胞外N-末端区域、四个跨膜结构域和一个大的胞质结构域组成。