FITC标记的锌指蛋白318抗体
产品名称： FITC标记的锌指蛋白318抗体
英文名称： Anti-ZNF318/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZNF318/FITC Conjugated antibody
FITC标记的锌指蛋白318抗体
| 产品编号 | bs-11414R-FITC |
| 英文名称 | Anti-ZNF318/FITC |
| 中文名称 | FITC标记的锌指蛋白318抗体 |
| 别 名 | Endocrine Regulatory Protein; HGNC13578; HRIHFB2436; ZFP318; Zinc Finger Protein 318; ZN318_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 内分泌病 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 251kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZNF318 (1077-1125aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ZNF318 is a 2279 amino acid endocrine regulatory protein that localizes to the nucleus. Highly expressed in testis, ovaries and kidneys, ZNF318 is a co-repressor of androgen receptor (AR)-mediated transcriptional activation and is thought to regulate transcription during spermatogenesis. ZNF318 interacts with the N-terminal domain of AR and contains two matrin-type zinc fingers. Two isoforms of ZNF318, designated TZF and TZF-L, are produced due to alternative splicing events. Each of these splice variants are thought to have unique roles in transcriptional regulation. While the TZF isoform functions as a repressor of AR-mediated transcriptional activation, the TZF-L isoform is thought to enhance AR-mediated transcriptional activation. Function: ZNF318 encodes a nuclear protein with a zinc finger motif of the Cys2-His2 type that is a novel corepressor of androgen receptor. Subunit: Interacts with the N-terminal domain of AR. Subcellular Location: Nuclear. Tissue Specificity: Expressed in endocrine tissue. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 2 matrin-type zinc fingers. Database links: Entrez Gene: 24149 Human SwissProt: Q5VUA4 Human SwissProt: Q99PP2 Mouse Unigene: 509718 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ZNF318是一种定位于细胞核的2279氨基酸内分泌调节蛋白。在睾丸、卵巢和肾脏中高表达，ZNF318是雄受体（AR）介导的转录激活的共阻遏物，并被认为在精子发生过程中调节转录。ZNF318与AR的N端结构域相互作用，含有两个苦参碱型锌指。ZNF318的两种异构体，指定TZF和TZF L，由于选择性剪接事件而产生。每个剪接变异体被认为在转录调控中具有独特的作用。虽然TZF亚型作为AR介导的转录激活的阻遏物，但TZF L亚型被认为增强AR介导的转录激活。