FITC标记的PSD95结合蛋白2抗体
产品名称： FITC标记的PSD95结合蛋白2抗体
英文名称： Anti-DLGAP2/FITC
产品编号： HZ-12139R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DLGAP2/FITC Conjugated antibody
FITC标记的PSD95结合蛋白2抗体
| 英文名称 | Anti-DLGAP2/FITC |
| 中文名称 | FITC标记的PSD95结合蛋白2抗体 |
| 别 名 | DLGAP2; SAPAP2; DAP-2; DAP2; Discs large (Drosophila) homolog associated protein 2; Discs large homolog associated protein 2; Disks large-associated protein 2; Dlgap2; DLGP2_HUMAN; PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2; SAPAP2; hide. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 118kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SAPAP2/DLGAP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: A guanylate kinase is a phosphotransferase that produces ADP and GDP from the substrates ATP and GMP. SAPAP2, also known as DAP-2 (Disks large-associated protein 2) and PSD-95/SAP90-binding protein 2, is a 1054 amino acid protein that localizes to the postsynaptic membrane of neuronal cells of the brain and kidney. SAPAP2 likely acts as a signaling molecule which interacts with the human genes DLG1 and DLG4/PSD-95. The gene encoding SAPAP2, DLGAP2, maps to human chromosome 8. Consisting of nearly 146 million base pairs, chromosome 8 encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that maps to chromosome 8. Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Subunit: Interacts with DLG1 and DLG4/PSD-95. Subcellular Location: Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Postsynaptic density of neuronal cells. Tissue Specificity: Expressed in brain and kidney. Similarity: Belongs to the SAPAP family. Database links: Entrez Gene: 9228 Human Entrez Gene: 244310 Mouse Entrez Gene: 116681 Rat Omim: 605438 Human SwissProt: Q9P1A6 Human SwissProt: Q8BJ42 Mouse SwissProt: P97837 Rat Unigene: 113287 Human Unigene: 404697 Mouse Unigene: 10705 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
鸟苷酸激酶是一种磷酸转移酶，从底物ATP和GMP中产生ADP和GDP。SAPAP2，也称为DAP-2（盘大相关蛋白2）和PSD-95/SAP90结合蛋白2，是一种1054氨基酸蛋白，定位于脑和肾的神经细胞的突触后膜。SAPAP2可能作为与人类基因DLG1和DLG4/PSD-95相互作用的信号分子。编码SAPAP2、DLGAP2的基因映射到人类第8号染色体。8号染色体由近1.46亿个碱基对组成，编码800多个基因，与各种疾病和恶性肿瘤有关。精神分裂症、双相情感障碍、8三体、Pfeiffer综合征、先天性甲状腺功能减退、Waardenburg综合征和一些白血病和淋巴瘤被认为是由于映射到8号染色体的特定基因的缺陷而发生的。