FITC标记的染色体卷曲螺旋域包含蛋白1抗体
产品名称： FITC标记的染色体卷曲螺旋域包含蛋白1抗体
英文名称： Anti-GEMC1/FITC
产品编号： HZ-13332R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-GEMC1/FITC Conjugated antibody
FITC标记的染色体卷曲螺旋域包含蛋白1抗体
| 英文名称 | Anti-GEMC1/FITC |
| 中文名称 | FITC标记的染色体卷曲螺旋域包含蛋白1抗体 |
| 别 名 | GEMC1; Geminin coiled coil domain containing protein 1; Gm606; GEMC1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GEMC1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: GEMC1 is a 334 amino acid nuclear protein that regulates DNA replication by promoting the recruitment of Cdc45 onto replication origins. A member of the GEMC1 family, GEMC1 is highly phosphorylated and interacts with chromatin during formation of the pre-replication complex. The gene encoding GEMC1 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. Function: Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins. Subcellular Location: Nucleus (By similarity). Note=Associates with chromatin during pre-replication complex (pre-RC) formation (By similarity). Post-translational modifications: Highly phosphorylated by CDK2; stimulates initiation of DNA replication. Similarity: Belongs to the GEMC1 family. Database links: Entrez Gene: 647309 Human Entrez Gene: 239789 Mouse SwissProt: A6NCL1 Human SwissProt: Q3URY2 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
GEMC1是一种334氨基酸核蛋白，通过促进Cdc45在复制源上的募集来调节DNA复制。GEMC1是GEMC1家族的成员，在预复制复合物的形成过程中高度磷酸化并与染色质相互作用。编码GEMC1的基因映射到人类染色体3，其由约1100个基因编码的约2亿1400万个碱基组成。值得注意的是，在第3号染色体上存在趋化因子受体基因簇和多种人类癌症相关基因座。染色体3短臂的特定区域在许多类型的癌细胞中被删除。染色体3上的关键抑癌基因编码凋亡介质RASSF1、细胞迁移调节因子HYAL1和血管生成抑制因子SEMA3B。马凡综合征、卟啉症、冯·希佩尔-林道综合征、成骨不全和Charcot-Marie-Tooth病是众多遗传病中的一些。与3号染色体有关。