FITC标记的Tat结合蛋白7抗体
产品名称： FITC标记的Tat结合蛋白7抗体
英文名称： Anti-TBP7/FITC
产品编号： HZ-18836R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TBP7/FITC Conjugated antibody
FITC标记的Tat结合蛋白7抗体
| 英文名称 | Anti-TBP7/FITC |
| 中文名称 | FITC标记的Tat结合蛋白7抗体 |
| 别 名 | 26S protease regulatory subunit 6B; 26S proteasome AAA ATPase subunit RPT3; 26S proteasome AAA-ATPase subunit RPT3; MB67 interacting protein; MB67-interacting protein; MIP224; Protease 26S subunit 6; Proteasome (prosome macropain) 26S subunit ATPase 4; Proteasome 19S S6; Proteasome 26S subunit ATPase 4; Proteasome 26S subunit, ATPase, 4; PRS6B_HUMAN; PSMC4; RPT3; S6; Tat binding protein 7; TAT-binding protein 7; TBP 7; TBP-7. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Cat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TBP7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Subcellular Location: Cytoplasm. Nucleus. Similarity: Belongs to the AAA ATPase family. Database links: Entrez Gene: 5704 Human Entrez Gene: 737578 Chimpanzee Entrez Gene: 510029 Cow Entrez Gene: 23996 Mouse Entrez Gene: 100341658 Rabbit Entrez Gene: 117262 Rat Entrez Gene: 398853 Xenopus laevis Entrez Gene: 493372 Xenopus tropicalis Entrez Gene: 326884 Zebrafish Omim: 602707 Human SwissProt: Q3T030 Cow SwissProt: P43686 Human SwissProt: P54775 Mouse SwissProt: Q63570 Rat Unigene: 211594 Human Unigene: 29582 Mouse Unigene: 11341 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
26S蛋白酶体是由2个复合物、一个20S核和一个19S调节剂组成的高度有序的多催化蛋白酶复合物。20S核由4个环组成，其中有28个不相同的亚基；2个环由7个α亚基组成，2个环由7个β亚基组成。19S调节器由一个包含6个ATPase亚基和2个非ATPase亚基的基座和一个最多包含10个非ATPase亚基的盖子组成。蛋白酶体以高浓度分布在真核细胞中，在非溶酶体途径中以ATP/泛素依赖的过程切割肽。该基因编码ATP酶家族的一个成员，它是19S调节亚基的一个组成部分，在26S蛋白酶体组装中起作用。编码的蛋白质与肝细胞癌蛋白Gangyyin相互作用，也可能通过与亲和素-1的相互作用在帕金森病中发挥作用。另一种编码多个异构体的剪接转录变体已被观察到该基因。[ RefSeq，JUL 2012 ]