FITC标记的NFKB激活蛋白抗体
产品名称： FITC标记的NFKB激活蛋白抗体
英文名称： Anti-NKAP/FITC
产品编号： HZ-12400R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NKAP/FITC Conjugated antibody
FITC标记的NFKB激活蛋白抗体
| 英文名称 | Anti-NKAP/FITC |
| 中文名称 | FITC标记的NFKB激活蛋白抗体 |
| 别 名 | NF-kappa-B-activating protein; Nkap; NKAP_HUMAN; Nuclear NF kappaB activating protein; Nuclear NF kappa B activating protein; NFkB activating protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 染色质和核信号 信号转导 干细胞 转录调节因子 淋巴细胞 t-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NKAP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NFκB, a pleiotropic transcription factor, is present in almost all cell types and is involved in many biological processes including inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFκB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFκB1/p105, NFκB1/p50, REL and NFκB2/p52. This complex is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NKAP (NF-κ-B-activating protein) is a 415 amino acid nuclear protein that regulates TNF and IL1-induced NFκB activation. As component of a DNA-binding complex, NKAP also functions as a transcriptional repressor that acts on NOTCH target genes. Loss of NKAP blocks the development of αβT- cells, suggesting that it is required for their maturation through repression of NOTCH genes. Function: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. Subunit: Component of the Notch corepressor complex. Interacts with CIR1 and HDAC3. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the UPF0396 family. Database links: Entrez Gene: 79576 Human Omim: 300766 Human SwissProt: Q8N5F7 Human Unigene: 522771 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
转录因子NFκB，A pleiotropic，几乎所有的细胞类型是present in and is involved in many生物学过程，包括炎症、免疫、细胞生长、分化、凋亡与tumorigenesis。NFκB是同性恋或heterodimeric formed by the相对复杂的含蛋白样域关系/ P65，relb，nfκb1 / P105 nfκb1 / P50，关系和nfκb2 /分析。这是controlled by各种复杂的翻译后修饰机理和Subcellular区室化as well as by相互作用以及其他cofactors corepressors金。nkap（NF -κB活化蛋白）是核蛋白，415氨基酸对TNF和IL-1诱导的NFκB活化。你的DNA结合复合物的分量，nkap also功能有转录抑制Notch靶基因，我们的行为。nkap loss of the development ofαβt块-细胞，这表明它是required for their成熟通过Notch基因的压制。