DERA,脱氧核糖磷酸醛缩酶样抗体

产品编号HZ-14279R
英文名称DERA
中文名称脱氧核糖磷酸醛缩酶样抗体
别 名Deoxyriboaldolase; 2 deoxyribose 5 phosphate aldolase homolog C. elegans; CGI 26; CGI26; CGI-26; DEOC; DEOC_HUMAN; Deoxyriboaldolase; Deoxyribose phosphate aldolase like; DERA; Phosphodeoxyriboaldolase; Putative deoxyribose phosphate aldolase; Putative deoxyribose-phosphate aldolase.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 发育生物学 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
DERA,脱氧核糖磷酸醛缩酶样抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DERA
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DERA,脱氧核糖磷酸醛缩酶样抗体PubMedPubMed
产品介绍background:
DERA is a 318 amino acid member of the deoC/fbaB aldolase protein family. Involved in the carbohydrate degradation pathway, DERA catalyzes the conversion of 2-deoxy-D-ribose 5-phosphate to D-glyceraldehyde 3-phosphate and an acetyldehyde. The gene that encodes DERA maps to human chromosome 12, which encodes over 1,100 genes within 132 million bases, making up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster, which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.

Function:
Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.

Similarity:
Belongs to the deoC/fbaB aldolase family. DeoC type 2 subfamily.

Gene ID:
51071

Database links:
Entrez Gene: 51071 Human
SwissProt: Q9Y315 Human
Unigene: 39429 Human

DERA,脱氧核糖磷酸醛缩酶样抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.