磷酸化蛋白激酶PKMYT1(Ser83)抗体
产品名称： 磷酸化蛋白激酶PKMYT1(Ser83)抗体
英文名称： Phospho-PKMYT1 (Ser83)
产品编号： hz-3296R
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 IF=1:100-500
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Rabbit Anti-Phospho-PKMYT1 (Ser83) antibody
| 产品编号 | hz-3296R |
| 英文名称 | Phospho-PKMYT1 (Ser83) |
| 中文名称 | 磷酸化蛋白激酶PKMYT1(Ser83)抗体 |
| 别 名 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Myt1 kinase; PMYT1_HUMAN. |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 免疫学 神经生物学 信号转导 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human PKMYT1 around the phosphorylation site of Ser83:RV(p-S)FR |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008] Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Subunit: Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1. Subcellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Post-translational modifications: Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. Contains 1 protein kinase domain. Gene ID: 9088 Database links:
Entrez Gene: 9088 Human Entrez Gene: 268930 Mouse Entrez Gene: 287101 Rat Omim: 602474 Human SwissProt: Q99640 Human SwissProt: Q9ESG9 Mouse Unigene: 77783 Human Unigene: 182193 Mouse
Unigene: 204349 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |