FITC标记的LNX2蛋白抗体
产品名称： FITC标记的LNX2蛋白抗体
英文名称： Anti-LNX2/FITC
产品编号： HZ-18321R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LNX2/FITC Conjugated antibody
FITC标记的LNX2蛋白抗体
| 英文名称 | Anti-LNX2/FITC |
| 中文名称 | FITC标记的LNX2蛋白抗体 |
| 别 名 | FLJ12933; FLJ23932; FLJ38000; Ligand of Numb protein X 2; LNX 2; LNX2; LNX2_HUMAN; MGC46315; Numb binding protein 2; Numb-binding protein 2; PDZ domain containing ring finger 1; PDZ domain containing RING finger protein 1; PDZ domain-containing RING finger protein 1; PDZRN 1; PDZRN1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 76kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LNX2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: LNX2 (LIGAND OF NUMB PROTEIN X2, PDZ DOMAIN-CONTAINING RING FINGER PROTEIN 1, PDZRN1), which interacts with mammalian Numb and NumbL, contains a RING finger domain, followed by a motif similar to a PTB-binding motif and 4 PDZ domains. Lnx2 and Lnx1 (a proposed relative) are multimodular proteins that bind Numb, a cell fate determinant, through their NPXY motifs. Studies may suggest that Lnx proteins act as molecular scaffolds that promote the aggregation of unrelated, interacting proteins, such as Numb, to definitive subcellular sites. The LNX2 gene maps to chromosome 13q12.2 based on an alignment of the LNX2 sequence with the genomic sequence. Lnx proteins may form large networks by homomeric binding, and their expression patterns overlap with those of the Numb proteins. Furthermore, studies also suggest that the oligomerization of Lnx2 and Numb binding occurs simultaneously. Subunit: Interacts with the phosphotyrosine interaction domain of NUMB. Similarity: Contains 4 PDZ (DHR) domains. Contains 1 RING-type zinc finger. Database links: Entrez Gene: 222484 Human Omim: 609733 Human SwissProt: Q8N448 Human Unigene: 132359 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
LnX2（Numb蛋白X2，配体的PDZ结构domain-containing环指蛋白1，pdzrn1），这与哺乳动物的麻木，Numbl交互，包含一个环指结构域，其次是主题类似于PTB结合基序和4个PDZ结构域。LNX2和LNX1（拟议的相对）是多模块蛋白，结合NUMB，一种细胞命运决定因子，通过它们的NPXY基序。研究表明LNX蛋白作为分子支架，促进无关，聚集相互作用的蛋白质，如麻木，最终亚细胞位点。Lnx2基因基于Lnx2序列与基因组序列的比对而映射到染色体13q1.2。LNX蛋白可通过同型结合形成大的网络，其表达模式与NUMB蛋白重叠。此外，研究还表明，LNX2和NUMB结合的寡聚化同时发生。