FITC标记的转录因子SP6抗体
产品名称： FITC标记的转录因子SP6抗体
英文名称： Anti-SP6/KLF14/FITC
产品编号： HZ-12704R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SP6/KLF14/FITC Conjugated antibody
FITC标记的转录因子SP6抗体
| 英文名称 | Anti-SP6/KLF14/FITC |
| 中文名称 | FITC标记的转录因子SP6抗体 |
| 别 名 | MGC119665; Epfn; EPIPROFIN; KLF14; Krueppel-like factor 14; MGC119662; MGC119663; MGC119664; Sp6; Sp6 transcription factor; SP6_HUMAN; Transcription factor Sp6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞周期蛋白 转录调节因子 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SP6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. Sp6, also known as EPFN, EPIPROFIN or KLF14, is a 376 amino acid protein that localizes to the nucleus and contains three C2H2-type zinc fingers. Expressed ubiquitously with higher expression in developing teeth, hair follicles and limb buds, Sp6 functions to bind GC-rich sequences and related GT and CACCC boxes, thereby promoting cellular proliferation. Human Sp6 shares 96% sequence homology with its mouse counterpart, suggesting a conserved role between species. The gene encoding Sp6 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Function: Promotes cell proliferation. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous. Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers. Database links: Entrez Gene: 80320 Human Entrez Gene: 83395 Mouse Omim: 608613 Human SwissProt: Q3SY56 Human SwissProt: Q9ESX2 Mouse Unigene: 253603 Human Unigene: 156282 Mouse Unigene: 476096 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
锌指蛋白含有DNA结合结构域，具有多种功能，其中大多数包含某种形式的转录激活或抑制。Sp6，也称为EPFN、EPIPROFIN或KLF14，是一种376个氨基酸蛋白，定位于细胞核，含有三个C2H2型锌指。Sp6在发育中的牙齿、毛囊和肢芽中普遍表达并具有较高表达，具有结合富含GC的序列和相关的GT和CACCC盒的功能，从而促进细胞增殖。人SP6与小鼠对应共有96%个序列同源性，提示物种间具有保守的作用。编码SP6的基因映射到人类17号染色体，其包含超过2.5%的人类基因组并编码超过1200个基因。