FITC标记的白介素-24抗体
产品名称： FITC标记的白介素-24抗体
英文名称： Anti-IL24/FITC
产品编号： HZ-10576R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-IL24/FITC Conjugated antibody
FITC标记的白介素-24抗体
| 英文名称 | Anti-IL24/FITC |
| 中文名称 | FITC标记的白介素-24抗体 |
| 别 名 | IL24_HUMAN; Interleukin-24; IL-24; Melanoma differentiation-associated gene 7 protein; MDA-7; Suppression of tumorigenicity 16 protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 细胞因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL24 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Function: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. Subcellular Location: Secreted (Potential). Tissue Specificity: Up-regulated in melanoma cells induced to terminally differentiate. Similarity: Belongs to the IL-10 family. Database links: Entrez Gene: 11009 Human Omim: 604136 Human SwissProt: Q13007 Human Unigene: 58831 Human Unigene: 728324 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码细胞因子IL10家族的成员。它被鉴定为黑色素瘤细胞终末分化过程中诱导的基因。该基因编码的蛋白可选择性诱导多种癌细胞凋亡。该基因的过度表达导致几个GADD家族基因的高表达，这些基因与诱导细胞凋亡有关。有丝分裂原激活蛋白激酶14(MAPK7/P38)和热休克蛋白27kDa蛋白1(HSPB2/HSP27)的磷酸化在黑色素瘤细胞中被诱导，而在正常永生化黑色素细胞中没有被诱导。另外，报道了编码不同亚型的剪接转录变体。[ RefSeq，JUL 2008 ]