FITC标记的核糖核苷酸还原酶亚基R2抗体
产品名称： FITC标记的核糖核苷酸还原酶亚基R2抗体
英文名称： Anti-RRM2/FITC
产品编号： HZ-7133R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RRM2/FITC Conjugated antibody
FITC标记的核糖核苷酸还原酶亚基R2抗体
| 英文名称 | Anti-RRM2/FITC |
| 中文名称 | FITC标记的核糖核苷酸还原酶亚基R2抗体 |
| 别 名 | R2; Ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase M2 subunit; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; RIR2_HUMAN; RR2; RR2M; RRM2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞周期蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RRM2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Ribonucleotide reductase is essential for the production and maintenance of the level of deoxyribonucleoside triphosphates (dNTPs) required for DNA synthesis. It is an enzymatic complex consisting of two nonidentical subunits, R1 and R2, which are inactive separately. R2, the smaller subunit, is localized to the cytoplasm. R2 is the limiting factor of the catalytic activity of the ribonucleotide reductase enzymatic complex. R2 expression is strictly correlated to the S-phase of the cell cycle, whereas R1 remains constant throughout all phases of the cell cycle. While R2 seems to be involved solely in the maintenance of dNTPs for DNA replication, a similar protein, p53R2, has been shown to be responsible for the production of dNTPs in response to DNA damage. Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Subunit: Heterodimer of a large and a small subunit. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family. Database links: Entrez Gene: 6241 Human Omim: 180390 Human SwissProt: P31350 Human Unigene: 226390 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
核苷酸还原酶是生产和维持DNA合成所需的脱氧核糖核苷酸三磷酸盐（dNTP）水平所必需的。它是由两个不相同的亚基R1和R2组成的酶复合物，它们分别是不活泼的。R2，较小的亚基，定位于细胞质。R2是核糖核酸酶还原酶复合物催化活性的限制因素。R2的表达与细胞周期的S期严格相关，而R1在细胞周期的所有阶段保持恒定。虽然R2似乎只参与维持dNTP用于DNA复制，但已证明类似的蛋白p53R2负责产生dNTP，以响应DNA损伤。