FITC标记的BTB/POZ结构域蛋白10抗体
产品名称： FITC标记的BTB/POZ结构域蛋白10抗体
英文名称： Anti-BTBD10/FITC
产品编号： HZ-8398R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-BTBD10/FITC Conjugated antibody
FITC标记的BTB/POZ结构域蛋白10抗体
| 产品编号 | bs-8398R-FITC |
| 英文名称 | Anti-BTBD10/FITC |
| 中文名称 | FITC标记的BTB/POZ结构域蛋白10抗体 |
| 别 名 | BTB (broad complex tramtrack and bric a brac pox virus and zinc finger) domain containing protein 10 ; BTB (POZ) domain containing 10; BTB domain containing 10; BTB/POZ domain-containing protein 10; GMRP 1; GMRP1; K+ channel tetramerization protein; BTBDA_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BTBD10 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The BTB (broad-complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. BTBD10 (BTB (POZ) domain containing 10), also known as GMRP1, is a ubiquitously expressed nuclear protein found at highest levels in adult testis, brain and small intestine and weakly expressed in colon, lung, liver, kidney, spleen,pancreas, thymus, prostate, heart and ovary. Down-regulated in glioma, BTBD10 binds PP2A (protein phosphatase 2A) to inhibit dephosphorylation of Akts and is suggested to be a suppressor of cell death as well as an enhancer of cell growth. BTBD10 contains one BTB (POZ) domain and is encoded by a gene mapping to human chromosome 11p15.2. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed. Highly expressed in adult brain, testis and small intestine and weakly expressed in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon. Down-regulated in glioma. Similarity: Contains 1 BTB (POZ) domain. Database links: Entrez Gene: 84280 Human Entrez Gene: 68815 Mouse Entrez Gene: 308890 Rat SwissProt: Q9BSF8 Human SwissProt: Q80X66 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
BTB（广泛的复合物，Tramtrack和BRIC BRAC）域，也称为POZ（痘病毒和锌指）结构域，是包含KalCH重复序列和/或C2H2型锌指的多个拷贝的N-末端同质二聚域。含有BTB结构域的蛋白质被认为是通过调控染色质结构和功能参与转录调控的。BTBD10（BTB（POZ）结构域，包含10），又称GMRP1，是在成年睾丸、脑和小肠中最高水平发现的广泛表达的核蛋白，在结肠、肺、肝、肾、脾、胰腺、胸腺、前列腺、心脏和卵巢中弱表达。在胶质瘤中下调，BTBD10结合PP2A（蛋白磷酸酶2A）来抑制Akts的去磷酸化，并被认为是细胞死亡的抑制因子，也是细胞生长的增强子。BTBD10包含一个BTB（POZ）结构域，并通过基因映射编码到人类染色体11p152。