NRG2 monoclonal antibody (M01), clone 3D2
产品名称： NRG2 monoclonal antibody (M01), clone 3D2
英文名称： NRG2 monoclonal antibody (M01), clone 3D2
产品编号： H00009542-M01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant NRG2.
- Immunogen:
- NRG2 (NP_004874, 116 a.a. ~ 215 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- SLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLD
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
- MSDS:
Download
- Publication Reference
- 1.
- Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant.
Frogne T, Benjaminsen RV, Sonne-Hansen K, Sorensen BS, Nexo E, Laenkholm AV, Rasmussen LM, Riese DJ 2nd, de Cremoux P, Stenvang J, Lykkesfeldt AE.Breast Cancer Res Treat. 2009 Mar;114(2):263-75. Epub 2008 Apr 14.
- Applications
- Western Blot (Tissue lysate)
- NRG2 monoclonal antibody (M01), clone 3D2. Western Blot analysis of NRG2 expression in human pancreas.
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged NRG2 is approximately 0.03ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 9542
- GeneBank Accession#:
- NM_004883
- Protein Accession#:
- NP_004874
- Gene Name:
- NRG2
- Gene Alias:
- Don-1,HRG2,NTAK
- Gene Description:
- neuregulin 2
- Omim ID:
- 603818
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described. [provided by RefSeq
- Other Designations:
- OTTHUMP00000159546,divergent of neuregulin-1,neural- and thymus-derived activator for ErbB kinases
- Gene Pathway